We Can Expect Effective Anti-Aging Drugs in the Coming Decade
The life expectancy of people has grown over time. But recent research has shown that late years are often marked with chronic diseases and ailments that considerably reduce the quality of life of seniors. Scientists over the world have been searching for new methods and drugs which can help to reduce the aging process in humans.
Possibly reversible causes of aging
Most of the new findings indicate a few main causes leading to aging. Mitigating any one of these causes will result in providing strength to the body and make it possible for people to stay healthy even in their old age. Some of the major causes are considered to be the following:
1. With time cells stop being replaced periodically. As we grow older, more and more cells stop reproducing and leak compounds which harm the surrounding cells and the whole body. These senescent cells eventually increase in number and often lead to various chronic illnesses.
2. Genes tend to start mutating over the years. Through the life, a human being’s DNA gets damaged little by little. The older a person is, the more tiny lesions are accumulated in the DNA. This damage may result in a myriad of health problems and aging in general. So it is a very promising domain of anti-aging research since if scientists learned how to repair DNA, people could theoretically live for extremely long periods.
Promising studies in the field of anti-aging
Scientists at different places are very close to figuring out a method which can safely delay the process of aging. According to successful recent studies there are a few possibilities that may become reality very soon:
1. A study conducted in 2014 by researchers from Cardiff University, Wales, proved efficiency of a new metformin drug. During clinical trials, it was given to patients of type 2 diabetes and the drug increased their life span by fifteen percent as compared to similar patients that didn’t take the drug.
2. Researchers at the University of New South Wales (UNSW) made a discovery in March, 2017, which even caught interest of NASA. They identified a metabolite called NAD+ which plays an important role as a regulator for protein-to-protein interactions controlling DNA repair. In the study, researchers injected NAD+ into old mice, which after some time made their cells similar to those of younger mice, as reported by Professor David Sinclair, lead author of the research.
3. Researchers from Erasmus University Medical Center located in Netherlands successfully tested a way to eliminate senescent cells in mice. The protective protein p53 is not able to reach senescent cells due to another protein known as FOXO4. However, the scientists managed to attach small parts of FOXO4 to p53, which made it possible for the latter to reach senescent cells. As a result, the modified protein applied to rapidly aging mice boosted their fur density, improved kidney functioning and increased their metabolism.
Numerous other new findings indicate that humans are likely to get reliable anti-aging drugs in the next decade. Several governments and agencies are showing interest in anti-aging research as it will substantially reduce the health expenditures while opening up numerous other possibilities, too.